The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling

Laurent-Rolle, Maudry; F. Boer, Elena; J. Lubick, Kirk; B. Wolfinbarger, James; Carmody, Aaron; Rockx, Barry; Liu, Wenjun; Ashour, Joseph; Lesley Shupert, W.; R. Holbrook, Michael; D.T. Barrett, Alan; W. Mason, Peter; E. Bloom, Marshall; García‐Sastre, Adolfo; A. Khromykh, Alexander; M. Best, Sonja

doi:10.1128/jvi.01161-09

Public

The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling

Published in Journal of Virology • Jan 27, 2010

Authors:

Maudry Laurent-Rolle

Elena F. Boer

Kirk J. Lubick

Abstract

Flaviviruses transmitted by arthropods represent a tremendous disease burden for humans, causing millions of infections annually. All vector-borne flaviviruses studied to date suppress host innate responses to infection by inhibiting alpha/beta interferon (IFN-alpha/beta)-mediated JAK-STAT signal tr...

Subject

Biology

Virology

Flavivirus

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