An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor–dependent signals

Yu, Jeffrey; J. Ruddy, Matthew; C. Wong, Grace; Sfintescu, Cornelia; J. Baker, Pamela; B. Smith, Jeffrey; T. Evans, R.; L. Gaffen, Sarah

doi:10.1182/blood-2005-09-010116

Public

An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor–dependent signals

Published in Blood • Jan 3, 2007

Authors:

Jeffrey Yu

Matthew J. Ruddy

Grace C. Wong

Abstract

IL-17 and its receptor are founding members of a novel family of inflammatory cytokines. IL-17 plays a pathogenic role in rheumatoid arthritis (RA)-associated bone destruction. However, IL-17 is also an important regulator of host defense through granulopoiesis and neutrophil trafficking. Therefore,...

Subject

Immunology

Porphyromonas gingivalis

Periodontal pathogen

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