Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol<sup>,</sup>

ter Haar, Ernst; Kowalski, Richard; Hamel, Ernest; M. Lin, Chii; E. Longley, Ross; P. Gunasekera, Sarath; S. Rosenkranz, Herbert; W. Day, Billy

doi:10.1021/bi9515127

Public

Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol,

Published in Biochemistry • Jan 1, 1996

Authors:

Ernst ter Haar

Richard Kowalski

Ernest Hamel

Abstract

Computer-assisted structure analysis indicated (+)-discodermolide, a polyhydroxylated alkatetraene lactone marine natural product, was an antimitotic compound, and we confirmed this prediction. Previous work had shown an accumulation of discodermolide-treated cells in the G2/M portion of the cell cy...

Subject

Antimitotic Agent

Tubulin

Microtubule

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