<i>IL28B</i> Polymorphism Is Associated with Both Side Effects and Clearance of Hepatitis C During Interferon-Alpha Therapy

E. Lotrich, Francis; M. Loftis, Jennifer; E. Ferrell, Robert; Rabinovitz, Mordechai; Hauser, Péter

doi:10.1089/jir.2010.0074

Public

IL28B Polymorphism Is Associated with Both Side Effects and Clearance of Hepatitis C During Interferon-Alpha Therapy

Published in Journal of Interferon & Cytokine Research • Dec 7, 2010

Authors:

Francis E. Lotrich

Jennifer M. Loftis

Robert E. Ferrell

Abstract

Interferon-α (IFN-α) treatment for hepatitis C virus (HCV) is complicated by depression and related neurovegetative side effects. Recent genome-wide scans identified IL28B gene polymorphisms that associated with HCV clearance. Whether the IL28B polymorphism is also associated with these adverse effe...

Subject

Internal medicine

Genotype

Gastroenterology

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