Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

F. Schlenk, Richard; Döhner, Konstanze; Krauter, Jürgen; Fröhling, Stefan; Corbacioglu, Andrea; Bullinger, Lars; Habdank, Marianne; Späth, Daniela; Morgan, Michael; Benner, Axel; Schlegelberger, Brigitte; Heil, Gerhard; Ganser, Arnold; Döhner, Hartmut

doi:10.1056/nejmoa074306

Public

Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

Published in New England Journal of Medicine • Apr 30, 2008

Authors:

Richard F. Schlenk

Konstanze Döhner

Jürgen Krauter

Abstract

BACKGROUND: Mutations occur in several genes in cytogenetically normal acute myeloid leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 gene (FLT3), the CCAAT/enhancer binding protein alpha gene (CEPBA), the myeloid-lymphoid or mixed-lineage leukemia gene (MLL), a...

Subject

NPM1

Myeloid leukemia

Neuroblastoma RAS viral oncogene homolog

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