The major murine systemic lupus erythematosus susceptibility locus, <i>Sle1</i> , is a cluster of functionally related genes

Morel, Laurence; Blenman, Kim; P. Croker, Byron; K. Wakeland, Edward

doi:10.1073/pnas.98.4.1787

Public

The major murine systemic lupus erythematosus susceptibility locus, Sle1 , is a cluster of functionally related genes

Published in Proceedings of the National Academy of Sciences • Jan 23, 2001

Authors:

Laurence Morel

Kim Blenman

Byron P. Croker

Abstract

The major murine systemic lupus erythematosus (SLE) susceptibility locus Sle1 is syntenic to a chromosomal region linked with SLE susceptibility in multiple human studies. Congenic analyses have shown that Sle1 breaks tolerance to chromatin, a necessary step for full disease induction that can be su...

Subject

Biology

Congenic

Locus (genetics)

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