A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate

Ruperto, Nicolino; Murray, Kevin; Gerloni, V.; Wulffraat, Nico; Knupp Feitosa de Oliveira, Sheila; Falcini, Fernanda; Doležalová, Pavla; Alessio, Maria; Burgos‐Vargas, Rubén; Corona, Fabrizia; Veselý, Richard; Foster, Helen; Davidson, Joyce; Zulian, Francesco; Asplin, L; Baildam, Eileen; Garcìa Consuegra, Julia; Özdoğan, Huri; K. Saurenmann, Rotraud; Joos, Rik; Pistorio, Angela; Woo, Pat; Martini, Alberto

doi:10.1002/art.20288

Public

A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate

Published in Arthritis & Rheumatism • Jul 1, 2004

Authors:

Nicolino Ruperto

Kevin Murray

V. Gerloni

Abstract

OBJECTIVE: To compare the safety and efficacy of parenteral methotrexate (MTX) at an intermediate dosage (15 mg/m(2)/week) versus a higher dosage (30 mg/m(2)/week) in patients with polyarticular-course juvenile idiopathic arthritis (JIA) who failed to improve while receiving standard dosages of MTX ...

Subject

Medicine

Methotrexate

Randomization

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