Patterns of Arginine and Nitric Oxide in Patients With Sickle Cell Disease With Vaso-occlusive Crisis and Acute Chest Syndrome

R. Morris, Claudia; A. Kuypers, Frans; Larkin, Sandra; Vichinsky, Elliott; Styles, Lori

doi:10.1097/00043426-200011000-00009

Public

Patterns of Arginine and Nitric Oxide in Patients With Sickle Cell Disease With Vaso-occlusive Crisis and Acute Chest Syndrome

Published in The American journal of pediatric hematology/oncology • Nov 1, 2000

Authors:

Claudia R. Morris

Frans A. Kuypers

Sandra Larkin

Abstract

PURPOSE: Our objective was to evaluate L-arginine and nitric oxide metabolite (NOx) levels in children with sickle cell disease (SCD) at steady-state and during vaso-occlusive crisis (VOC). Because alterations in nitric oxide production may have an important role in the pathophysiology of SCD, our s...

Subject

Nitric oxide

Vaso-occlusive crisis

Acute chest syndrome

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