Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Freiherr, Jessica; Hallschmid, Manfred; H. Frey, William; F. Brünner, Yvonne; D. Chapman, Colin; Hölscher, Christian; Craft, Suzanne; G. De Felice, Fernanda; Benedict, Christian

doi:10.1007/s40263-013-0076-8

Public

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Published in CNS Drugs • May 29, 2013

Authors:

Jessica Freiherr

Manfred Hallschmid

William H. Frey

Abstract

Research in animals and humans has associated Alzheimer's disease (AD) with decreased cerebrospinal fluid levels of insulin in combination with decreased insulin sensitivity (insulin resistance) in the brain. This phenomenon is accompanied by attenuated receptor expression of insulin and insulin-lik...

Subject

Insulin

Insulin resistance

Insulin receptor

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