Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

U. Neumann, Avidan; P. Lam, Nancy; Dahari, Harel; R. Gretch, David; E. Wiley, Thelma; J. Layden, Thomas; S. Perelson, Alan

doi:10.1126/science.282.5386.103

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Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

Shared by NobleBlocks on Oct 2, 1998 • 12:00 AM UTC

Authors:

Avidan U. Neumann

Nancy P. Lam

Harel Dahari

Abstract

To better understand the dynamics of hepatitis C virus and the antiviral effect of interferon-α-2b (IFN), viral decline in 23 patients during therapy was analyzed with a mathematical model. The analysis indicates that the major initial effect of IFN is to block virion production or release, with blo...

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