Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

U. Neumann, Avidan; P. Lam, Nancy; Dahari, Harel; R. Gretch, David; E. Wiley, Thelma; J. Layden, Thomas; S. Perelson, Alan

doi:10.1126/science.282.5386.103

Public

Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

Published in Science • Oct 2, 1998

Authors:

Avidan U. Neumann

Nancy P. Lam

Harel Dahari

Abstract

To better understand the dynamics of hepatitis C virus and the antiviral effect of interferon-alpha-2b (IFN), viral decline in 23 patients during therapy was analyzed with a mathematical model. The analysis indicates that the major initial effect of IFN is to block virion production or release, with...

Subject

Viral load

Interferon

Virus

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