Membrane Type 1 Matrix Metalloproteinase (MT1-MMP/MMP-14) Cleaves and Releases a 22-kDa Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Fragment from Tumor Cells

Egawa, Nagayasu; Koshikawa, Naohiko; Tomari, Taizo; Nabeshima, Kazuki; Isobe, Toshiaki; Seiki, Motoharu

doi:10.1074/jbc.m606993200

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Membrane Type 1 Matrix Metalloproteinase (MT1-MMP/MMP-14) Cleaves and Releases a 22-kDa Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Fragment from Tumor Cells

Published in Journal of Biological Chemistry • Oct 19, 2006

Authors:

Nagayasu Egawa

Naohiko Koshikawa

Taizo Tomari

Abstract

Proteolytic shedding is an important step in the functional down-regulation and turnover of most membrane proteins at the cell surface. Extracellular matrix metalloproteinase inducer (EMMPRIN) is a multifunctional glycoprotein that has two Ig-like domains in its extracellular portion and functions i...

Subject

Metalloproteinase

Matrix metalloproteinase

Extracellular matrix

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