mGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination

Ichise, Taeko; Kano, Masanobu; Hashimoto, Kouichi; Yanagihara, Dai; Nakao, Kazuki; Shigemoto, Ryuichi; Katsuki, Motoya; Aiba, Atsu

doi:10.1126/science.288.5472.1832

Public

mGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination

Published in Science • Jun 9, 2000

Authors:

Taeko Ichise

Masanobu Kano

Kouichi Hashimoto

Abstract

Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1alpha transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed nor...

Subject

Metabotropic glutamate receptor 1

Metabotropic glutamate receptor

Neuroscience

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