Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

S. Kobayashi, Koichi; Chamaillard, Mathias; Ogura, Yasunori; Henegariu, Octavian; Inohara, Naohiro; Núñez, Gabriel; A. Flavell, Richard

doi:10.1126/science.1104911

Public

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

Published in Science • Feb 3, 2005

Authors:

Koichi S. Kobayashi

Mathias Chamaillard

Yasunori Ogura

Abstract

The gene encoding the Nod2 protein is frequently mutated in Crohn's disease (CD) patients, although the physiological function of Nod2 in the intestine remains elusive. Here we show that protective immunity mediated by Nod2 recognition of bacterial muramyl dipeptide is abolished in Nod2-deficient mi...

Subject

NOD2

Muramyl dipeptide

Immunity

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