Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations inMYH

M. Sieber, Oliver; Lipton, Lara; Crabtree, Michael; Heinimann, Karl; Fidalgo, Paulo; Phillips, Robin; Bisgaard, Marie-Luise; F. Ørntoft, Torben; A. Aaltonen, Lauri; V. Hodgson, Shirley; Thomas, Huw; Tomlinson, Ian

doi:10.1056/nejmoa025283

Public

Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations inMYH

Published in New England Journal of Medicine • Feb 27, 2003

Authors:

Oliver M. Sieber

Lara Lipton

Michael Crabtree

Abstract

BACKGROUND: Germ-line mutations in the base-excision-repair gene MYH have been associated with recessive inheritance of multiple colorectal adenomas. Tumors from affected persons displayed excess somatic transversions of a guanine-cytosine pair to a thymine-adenine pair (G:C-->T:A) in the APC gene. ...

Subject

MUTYH

Germline mutation

Germline

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