PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

Shen, Yingjie; P. Tenney, Alan; A. Busch, Sarah; P. Horn, Kevin; X. Cuascut, Fernando; Liu, Kai; He, Zhigang; Silver, Jerry; G. Flanagan, John

doi:10.1126/science.1178310

Public

PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

Published in Science • Oct 15, 2009

Authors:

Yingjie Shen

Alan P. Tenney

Sarah A. Busch

Abstract

Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been identified. We showed that a transmembrane protein tyrosine phosphatase, PTPsigma, binds with high affinity to neural CSPGs. Binding involves th...

Subject

Chondroitin sulfate proteoglycan

Proteoglycan

Chondroitin sulfate

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