MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

Terunuma, Atsushi; Putluri, Nagireddy; Mishra, Prachi; A. Mathé, Ewy; H. Dorsey, Tiffany; Yi, Ming; A. Wallace, Tiffany; J. Issaq, Haleem; Zhou, Ming; Keith Killian, J.; Stevenson, Holly; D. Karoly, Edward; Hong Chan, King; Samanta, Susmita; A. Prieto, DaRue; Hsu, Tiffany; J. Kurley, Sarah; Putluri, Vasanta; Sonavane, Rajni; C. Edelman, Daniel; Wulff, Jacob; M. Starks, Adrienne; Yang, Yinmeng; A. Kittles, Rick; G. Yfantis, Harry; Hoon Lee, Dong; B. Ioffe, Olga; Schiff, Rachel; M. Stephens, Robert; S. Meltzer, Paul; D. Veenstra, Timothy; F. Westbrook, Thomas; Sreekumar, Arun; Ambs, Stefan

doi:10.1172/jci71180

Public

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

Published in Journal of Clinical Investigation • Dec 8, 2013

Authors:

Atsushi Terunuma

Nagireddy Putluri

Prachi Mishra

Abstract

Metabolic profiling of cancer cells has recently been established as a promising tool for the development of therapies and identification of cancer biomarkers. Here we characterized the metabolomic profile of human breast tumors and uncovered intrinsic metabolite signatures in these tumors using an ...

Subject

Breast cancer

Cancer research

Cancer

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