Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene

Cartron, Guillaume; Dacheux, Laurent; Salles, Gilles; Solal‐Céligny, Philippe; Bardos, P.; Colombat, Philippe; Watier, Hervé

doi:10.1182/blood.v99.3.754

Public

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene

Published in Blood • Feb 1, 2002

Authors:

Guillaume Cartron

Laurent Dacheux

Gilles Salles

Abstract

Given that the FcgammaRIIIa receptor 158V allotype displays a higher affinity for human immunoglobulin G1 and increased antibody-dependent cellular cytotoxicity, the aim of this study was to determine the influence of that FCGR3A polymorphism on the therapeutic response to rituximab, an anti-CD20 hu...

Subject

Fc receptor

Monoclonal antibody

Antibody

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