Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways

Bouaziz, W.; Funck‐Brentano, Thomas; Lin, H.; Marty, Caroline; Ea, Hang‐Korng; Haÿ, Eric; Cohen‐Solal, Martine

doi:10.1186/s13075-015-0540-6

Public

Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways

Published in Arthritis Research & Therapy • Feb 4, 2015

Authors:

W. Bouaziz

Thomas Funck‐Brentano

H. Lin

Abstract

INTRODUCTION: Sclerostin is a Wnt inhibitor produced by osteocytes that regulates bone formation. Because bone tissue contributes to the development of osteoarthritis (OA), we investigated the role of sclerostin in bone and cartilage in a joint instability model in mice. METHODS: Ten-week-old SOST-k...

Subject

Sclerostin

Wnt signaling pathway

Rheumatology

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