HIF‐1 and AP‐1 Cooperate to Increase Gene Expression in Hypoxia: Role of MAP Kinases

Michiels, Carine; Minet, Emmanuel; Michel, Gaëtan; Mottet, Denis; Piret, Jean‐Pascal; Raes, Martine

doi:10.1080/15216540252774766

Public

HIF‐1 and AP‐1 Cooperate to Increase Gene Expression in Hypoxia: Role of MAP Kinases

Published in IUBMB Life • Jul 1, 2001

Authors:

Carine Michiels

Emmanuel Minet

Gaëtan Michel

Abstract

HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several...

Subject

Hypoxia (environmental)

Kinase

Transcription factor

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