Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease.

Sagredo, Onintza; González, Sara; Aroyo, Ilia; Ruth Pazos, María; Benito, Cristina; Lastres-Becker, Isabel; P Romero, Juan; M Tolón, Rosa; Mechoulam, Raphael; Brouillet, Emmanuel; Romero, Julián; Fernández-Ruiz, Javier

doi:10.1002/glia.20838

Public

Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease.

Shared by NobleBlocks on Aug 15, 2009 • 12:00 AM UTC

Authors:

Onintza Sagredo

Sara González

Ilia Aroyo

Abstract

Cannabinoid agonists might serve as neuroprotective agents in neurodegenerative disorders. Here, we examined this hypothesis in a rat model of Huntington's disease (HD) generated by intrastriatal injection of the mitochondrial complex II inhibitor malonate. Our results showed that only compounds abl...

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