Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses

Ohtaki, Hirokazu; Ylöstalo, Joni; Foraker, Jessica; P. Robinson, Andrew; L. Reger, Roxanne; Shioda, Seiji; J. Prockop, Darwin

doi:10.1073/pnas.0803670105

Public

Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses

Published in Proceedings of the National Academy of Sciences • Sep 15, 2008

Authors:

Hirokazu Ohtaki

Joni Ylöstalo

Jessica Foraker

Abstract

Human mesenchymal stromal cells (hMSCs) were injected into the hippocampus of adult mice 1 day after transient global ischemia. The hMSCs both improved neurologic function and markedly decreased neuronal cell death of the hippocampus. Microarray assays indicated that ischemia up-regulated 586 mouse ...

Subject

Microglia

Immune system

Mesenchymal stem cell

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!