Natural Selection of Human Embryos: Impaired Decidualization of Endometrium Disables Embryo-Maternal Interactions and Causes Recurrent Pregnancy Loss

S. Salker, Madhuri; Teklenburg, Gijs; Molokhia, Mariam; Lavery, Stuart; Trew, Geoffrey; Aojanepong, Tepchongchit; J. Mardon, Helen; U. Lokugamage, Amali; Rai, Raj; Landles, Christian; A.J. Roelen, Bernard; Quenby, Siobhan; Kuijk, Ewart; Kavelaars, Annemieke; J. Heijnen, Cobi; Regan, Lesley; Macklon, Nick; J. Brosens, Jan

doi:10.1371/journal.pone.0010287

Public

Natural Selection of Human Embryos: Impaired Decidualization of Endometrium Disables Embryo-Maternal Interactions and Causes Recurrent Pregnancy Loss

Published in PLoS ONE • Apr 21, 2010

Authors:

Madhuri S. Salker

Gijs Teklenburg

Mariam Molokhia

Abstract

BACKGROUND: Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages, is widely attributed either to repeated chromosomal instability in the conceptus or to uterine factors that are poorly defined. We tested the hypothesis that abnormal cyclic differentiation of endometrial stro...

Subject

Decidualization

Endometrium

Embryo

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