High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory   Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance

A. Kühn, Andrea; Kempf, Florian; Brücke, Christof; Gaynor Doyle, L.; Martínez‐Torres, Irene; Pogosyan, Alek; Trottenberg, Thomas; Kupsch, Andreas; Schneider, Gerd‐Helge; Hariz, M; Vandenberghe, Wim; Nuttin, Bart; Brown, Peter

doi:10.1523/jneurosci.0282-08.2008

Public

High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance

Published in Journal of Neuroscience • Jun 11, 2008

Authors:

Andrea A. Kühn

Florian Kempf

Christof Brücke

Abstract

High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severe Parkinson's disease (PD), but its mechanism of action is unclear. Exaggerated oscillatory synchronization in the beta (13-30 Hz) frequency band has been associated with bradykines...

Subject

Subthalamic nucleus

Local field potential

Deep brain stimulation

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