Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.

P Saunders, Sean; S M Goh, Christabelle; J Brown, Sara; N A Palmer, Colin; M Porter, Rebecca; Cole, Christian; E Campbell, Linda; Gierlinski, Marek; J Barton, Geoffrey; Schneider, Georg; Balmain, Allan; R Prescott, Alan; Weidinger, Stephan; Baurecht, Hansjörg; Kabesch, Michael; Gieger, Christian; Lee, Young-Ae; Tavendale, Roger; Mukhopadhyay, Somnath; W Turner, Stephen; B Madhok, Vishnu; M Sullivan, Frank; Relton, Caroline; Burn, John; Meggitt, Simon; H Smith, Catherine; A Allen, Michael; N W N Barker, Jonathan; J Reynolds, Nick; J Cordell, Heather; D Irvine, Alan; H Irwin McLean, W; Sandilands, Aileen; G Fallon, Padraic

doi:10.1016/j.jaci.2013.08.046

Public

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.

Shared by NobleBlocks on Nov 1, 2013 • 12:00 AM UTC

Authors:

Sean P Saunders

Christabelle S M Goh

Sara J Brown

Abstract

BACKGROUND: Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin gene predisposing to development of AD. Support for barrier deficiency initiating AD came from flaky tail mice, which have a frameshift mutati...

Subject

Allergy

Atopic dermatitis

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