Extracellular DNA traps promote thrombosis

A. Fuchs, Tobias; Brill, Alexander; Duerschmied, Daniel; Schatzberg, Daphne; Monestier, Marc; D. Myers, Daniel; K. Wrobleski, Shirley; W. Wakefield, Thomas; H. Hartwig, John; D. Wagner, Denisa

doi:10.1073/pnas.1005743107

Public

Extracellular DNA traps promote thrombosis

Published in Proceedings of the National Academy of Sciences • Aug 23, 2010

Authors:

Tobias A. Fuchs

Alexander Brill

Daniel Duerschmied

Abstract

Neutrophil extracellular traps (NETs) are part of the innate immune response to infections. NETs are a meshwork of DNA fibers comprising histones and antimicrobial proteins. Microbes are immobilized in NETs and encounter a locally high and lethal concentration of effector proteins. Recent studies sh...

Subject

Neutrophil extracellular traps

Thrombus

Thrombosis

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