Highly Enantioselective Construction of Spiro[<i>4H</i>-pyran-3,3′-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine

Chen, Wenbing; Wu, Zhijun; Pei, Qing‐Lan; Cun, Linfeng; Zhang, Xiaomei; Yuan, Wei‐Cheng

doi:10.1021/ol1009224

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Highly Enantioselective Construction of Spiro[4H-pyran-3,3′-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine

Published in Organic Letters • Jun 14, 2010

Authors:

Wenbing Chen

Zhijun Wu

Qing‐Lan Pei

Abstract

The first enantioselective organocatalytic two- and three-component reactions via a domino Knoevenagel/Michael/cyclization sequence with cupreine as catalyst have been developed. A wide range of optically active spiro[4H-pyran-3,3'-oxindoles] were obtained in excellent yields (up to 99%) with good t...

Subject

Domino

Knoevenagel condensation

Enantioselective synthesis

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