Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population.

Chen, Dan; Tian, Tian; Wang, Haifeng; Liu, Hongliang; Hu, Zhibin; Wang, Yi; Liu, Yanhong; Ma, Hongxia; Fan, Weiwei; Miao, Ruifen; Sun, Weiwei; Wang, Yi; Qian, Ji; Jin, Li; Wei, Qingyi; Shen, Hongbing; Huang, Wei; Lu, Daru

doi:10.1097/fpc.0b013e328316d8d8

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Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population.

Shared by NobleBlocks on Jan 1, 2009 • 12:00 AM UTC

Authors:

Dan Chen

Tian Tian

Haifeng Wang

Abstract

BACKGROUND AND OBJECTIVE: Most of the carcinogenic effects of polycyclic aromatic hydrocarbons present in tobacco smoke are mediated by the aryl hydrocarbon receptor (AHR), a ligand-dependent transcription factor that regulates tobacco-induced expression of carcinogen metabolic enzymes. We hypothesi...

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