Clinical investigation in duchenne dystrophy: 2. Determination of the “power” of therapeutic trials based on the natural history

H. Brooke, Michael; M. Fenichel, Gerald; C. Griggs, Robert; R. Mendell, Jerry; T. Moxley, Richard; Philip Miller, J.; A. Province, Michael

doi:10.1002/mus.880060204

Public

Clinical investigation in duchenne dystrophy: 2. Determination of the “power” of therapeutic trials based on the natural history

Published in Muscle & Nerve • Feb 1, 1983

Authors:

Michael H. Brooke

Gerald M. Fenichel

Robert C. Griggs

Abstract

A prospective study of 114 patients with DMD provided data for "power" calculations for future therapeutic trials. There was a decline in strength of 0.4 units per year (on a 0-10 scale). Contractures of the iliotibial bands, hip flexors, and heel cords developed before 6 years. Contractures of othe...

Subject

Muscle contracture

Medicine

Natural history

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!