Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

Sirawaraporn, Worachart; Sathitkul, Tanajit; Sirawaraporn, Rachada; Yuthavong, Yongyuth; V. Santi, Daniel

doi:10.1073/pnas.94.4.1124

Public

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

Published in Proceedings of the National Academy of Sciences • Feb 18, 1997

Authors:

Worachart Sirawaraporn

Tanajit Sathitkul

Rachada Sirawaraporn

Abstract

Single and multiple mutations at residues 16, 51, 59, 108, and 164 of Plasmodium falciparum dihydrofolate reductase (pfDHFR) have been linked to antifolate resistance in malaria. We prepared and characterized all seven of the pfDHFR mutants found in nature, as well as six mutants not observed in nat...

Subject

Antifolate

Dihydrofolate reductase

Mutant

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