Immortalized Human Brain Endothelial Cells and Flow-Based Vascular Modeling: A Marriage of Convenience for Rational Neurovascular Studies

Cucullo, Luca; Couraud, Pierre-Olivier; Weksler, Babette; Romero, Ignacio-Andres; Hossain, Mohammed; Rapp, Edward; Janigro, Damir

doi:10.1038/sj.jcbfm.9600525

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Immortalized Human Brain Endothelial Cells and Flow-Based Vascular Modeling: A Marriage of Convenience for Rational Neurovascular Studies

Shared by NobleBlocks on Jul 4, 2007 • 12:00 AM UTC

Authors:

Luca Cucullo

Pierre-Olivier Couraud

Babette Weksler

Abstract

In evaluating drugs that enter or are excluded from the brain, novel pharmaceutical strategies are needed. For this reason, we have developed a humanized Dynamic In vitro Blood—Brain Barrier model (hDIV-BBB) based on a novel human brain vascular endothelial cell line (HCMEC/D3), which closely mimics...

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