High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses.

Pollara, Justin; Hart, Lydia; Brewer, Faraha; Pickeral, Joy; Z Packard, Beverly; A Hoxie, James; Komoriya, Akira; Ochsenbauer, Christina; C Kappes, John; Roederer, Mario; Huang, Ying; J Weinhold, Kent; D Tomaras, Georgia; F Haynes, Barton; C Montefiori, David; Ferrari, Guido

doi:10.1002/cyto.a.21084

Public

High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses.

Shared by NobleBlocks on Aug 1, 2011 • 12:00 AM UTC

Authors:

Justin Pollara

Lydia Hart

Faraha Brewer

Abstract

We have developed a high-throughput platform to detect the presence of HIV-1 and SIV-specific ADCC-mediating antibody responses. The assay is based on the hydrolysis of a cell-permeable fluorogenic peptide substrate containing a sequence recognized by the serine protease, Granzyme B (GzB). GzB is de...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!