Systemic inflammation disrupts the developmental program of white matter

Favrais, Géraldine; van de Looij, Yohan; Fleiss, Bobbi; Ramanantsoa, Nélina; Bonnin, Philippe; Stoltenburg‐Didinger, Gisela; Lacaud, Adrien; Saliba, Élie; Dammann, Olaf; Gallego, Jorge; Sizonenko, Stéphane; Hagberg, Henrik; Lelièvre, Vincent; Gressèns, Pierre

doi:10.1002/ana.22489

Public

Systemic inflammation disrupts the developmental program of white matter

Published in Annals of Neurology • May 20, 2011

Authors:

Géraldine Favrais

Yohan van de Looij

Bobbi Fleiss

Abstract

OBJECTIVE: Perinatal inflammation is a major risk factor for neurological deficits in preterm infants. Several experimental studies have shown that systemic inflammation can alter the programming of the developing brain. However, these studies do not offer detailed pathophysiological mechanisms, and...

Subject

White matter

Oligodendrocyte

Inflammation

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