α‐Synuclein contributes to GSK‐3β‐catalyzed Tau phosphorylation in Parkinson's disease models

Duka, Tetyana; Duka, Valeriy; N. Joyce, Jeffrey; Sidhu, Anita

doi:10.1096/fj.08-120410

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α‐Synuclein contributes to GSK‐3β‐catalyzed Tau phosphorylation in Parkinson's disease models

Shared by NobleBlocks on Apr 15, 2009 • 12:00 AM UTC

Authors:

Tetyana Duka

Valeriy Duka

Jeffrey N. Joyce

Abstract

ABSTRACT We have shown in the parknsonism‐inducing neurotoxin MPP + /MPTP model that α‐Synuclein (α‐Syn), a presynaptic protein causal in Parkinson's disease (PD), contributes to hyperphosphorylation of Tau (p‐Tau), a protein normally linked to tauopathies, such as Alzheimer's disease (AD). Here, we...

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