Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo.

G, McCaffrey; WD, Staatz; CA, Quigley; N, Nametz; MJ, Seelbach; CR, Campos; TA, Brooks; RD, Egleton; TP, Davis

doi:10.1111/j.1471-4159.2007.04943.x

Public

Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo.

Shared by NobleBlocks on Dec 1, 2007 • 12:00 AM UTC

Authors:

McCaffrey G

Staatz WD

Quigley CA

Abstract

Tight junctions (TJs) are major components of the blood-brain barrier (BBB) that physically obstruct the interendothelial space and restrict paracellular diffusion of blood-borne substances from the peripheral circulation to the CNS. TJs are dynamic structures whose intricate arrangement of oligomer...

Discussions