Tight junctions contain oligomeric protein assembly critical for maintaining blood–brain barrier integrity <i>in vivo</i>

McCaffrey, Gwen; D. Staatz, William; A. Quigley, Carolyn; Nametz, Nicole; J. Seelbach, Melissa; R. Campos, Chris; A. Brooks, Tracy; D. Egleton, Richard; P. Davis, Thomas

doi:10.1111/j.1471-4159.2007.04943.x

Public

Tight junctions contain oligomeric protein assembly critical for maintaining blood–brain barrier integrity in vivo

Published in Journal of Neurochemistry • Sep 2, 2007

Authors:

Gwen McCaffrey

William D. Staatz

Carolyn A. Quigley

Abstract

Tight junctions (TJs) are major components of the blood-brain barrier (BBB) that physically obstruct the interendothelial space and restrict paracellular diffusion of blood-borne substances from the peripheral circulation to the CNS. TJs are dynamic structures whose intricate arrangement of oligomer...

Subject

Occludin

Paracellular transport

Tight junction

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