The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

B'Chir, Wafa; Maurin, Anne‐Catherine; Carraro, Valérie; Avérous, Julien; Jousse, Céline; Muranishi, Yuki; Parry, Laurent; Stepien, Georges; Fafournoux, Pierre; Bruhat, Alain

doi:10.1093/nar/gkt563

Public

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

Published in Nucleic Acids Research • Jun 25, 2013

Authors:

Wafa B'Chir

Anne‐Catherine Maurin

Valérie Carraro

Abstract

In response to different environmental stresses, eIF2α phosphorylation represses global translation coincident with preferential translation of ATF4, a master regulator controlling the transcription of key genes essential for adaptative functions. Here, we establish that the eIF2α/ATF4 pathway direc...

Subject

ATF4

Autophagy

Integrated stress response

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