High Population Frequencies of APOL1 Risk Variants Are Associated with Increased Prevalence of Non-Diabetic Chronic Kidney Disease in the Igbo People from South-Eastern Nigeria

Ulasi, Ifeoma; Tzur, Shay; G. Wasser, Walter; Shemer, Revital; Kruzel, Etty; Feigin, Elena; Ijoma, CK; Onodugo, Obinna; Okoye, Julius; Arodiwe, Ejikeme; A. Ifebunandu, Ngozi; Chukwuka, Chinwe; C. Onyedum, Cajetan; Nkemdilim Ijoma, Uchenna; Okechukwu Nna, Emmanuel; Onuigbo, Macaulay; Rosset, Saharon; Skorecki, Karl

doi:10.1159/000353223

Public

High Population Frequencies of APOL1 Risk Variants Are Associated with Increased Prevalence of Non-Diabetic Chronic Kidney Disease in the Igbo People from South-Eastern Nigeria

Published in Nephron Clinical Practice • Jul 13, 2013

Authors:

Ifeoma Ulasi

Shay Tzur

Walter G. Wasser

Abstract

BACKGROUND: Continental Africa is facing an epidemic of chronic kidney disease (CKD). APOL1 risk variants have been shown to be strongly associated with an increased risk for non-diabetic kidney disease including HIV nephropathy, primary non-monogenic focal and segmental glomerulosclerosis, and hype...

Subject

Medicine

Kidney disease

Odds ratio

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