Interaction of 1‐Methyl‐4‐Phenylpyridinium Ion (MPP<sup>+</sup>) and Its Analogs with the Rotenone/Piericidin Binding Site of NADH Dehydrogenase

R. Ramsay, Rona; Krueger, M.; K. Youngster, Stephen; R. Gluck, Martin; E. Casida, John; P. Singer, Thomas

doi:10.1111/j.1471-4159.1991.tb11409.x

Public

Interaction of 1‐Methyl‐4‐Phenylpyridinium Ion (MPP+) and Its Analogs with the Rotenone/Piericidin Binding Site of NADH Dehydrogenase

Published in Journal of Neurochemistry • Apr 1, 1991

Authors:

Rona R. Ramsay

M. Krueger

Stephen K. Youngster

Abstract

Nigrostriatal cell death in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease results from the inhibition of mitochondrial respiration by 1-methyl-4-phenylpyridinium (MPP+). MPP+ blocks electron flow from NADH dehydrogenase to coenzyme Q at or near the same site as do r...

Subject

Rotenone

Stereochemistry

Chemistry

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