Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase.

RR, Ramsay; MJ, Krueger; SK, Youngster; MR, Gluck; JE, Casida; TP, Singer

doi:10.1111/j.1471-4159.1991.tb11409.x

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Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase.

Shared by NobleBlocks on Apr 1, 1991 • 12:00 AM UTC

Authors:

Ramsay RR

Krueger MJ

Youngster SK

Abstract

Nigrostriatal cell death in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease results from the inhibition of mitochondrial respiration by 1-methyl-4-phenylpyridinium (MPP+). MPP+ blocks electron flow from NADH dehydrogenase to coenzyme Q at or near the same site as do r...

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