Bosentan Therapy for Pulmonary Arterial Hypertension

J. Rubin, Lewis; B. Badesch, David; J. Barst, Robyn; Galiè, Nazzareno; M. Black, Carol; Keogh, Anne; Pulido, Tomás; Frost, Adaani; Roux, Sébastiên; Leconte, Isabelle; J. Landzberg, Michael; Simonneau, Gérald

doi:10.1056/nejmoa012212

Public

Bosentan Therapy for Pulmonary Arterial Hypertension

Published in New England Journal of Medicine • Mar 21, 2002

Authors:

Lewis J. Rubin

David B. Badesch

Robyn J. Barst

Abstract

BACKGROUND: Endothelin-1 is a potent vasoconstrictor and smooth-muscle mitogen. In a preliminary study, the orally administered dual endothelin-receptor antagonist bosentan improved exercise capacity and cardiopulmonary hemodynamics in patients with pulmonary arterial hypertension. The present trial...

Subject

Bosentan

Medicine

Endothelin receptor antagonist

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