Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Diabetes; Saxena, Richa; F Voight, Benjamin; Lyssenko, Valeriya; P Burtt, Noël; I W de Bakker, Paul; Chen, Hong; J Roix, Jeffrey; Kathiresan, Sekar; N Hirschhorn, Joel; J Daly, Mark; E Hughes, Thomas; Groop, Leif; Altshuler, David; Almgren, Peter; C Florez, Jose; Meyer, Joanne; Ardlie, Kristin; Bengtsson Boström, Kristina; Isomaa, Bo; Lettre, Guillaume; Lindblad, Ulf; N Lyon, Helen; Melander, Olle; Newton-Cheh, Christopher; Nilsson, Peter; Orho-Melander, Marju; Råstam, Lennart; K Speliotes, Elizabeth; Taskinen, Marja-Riitta; Tuomi, Tiinamaija; Guiducci, Candace; Berglund, Anna; Carlson, Joyce; Gianniny, Lauren; Hackett, Rachel; Hall, Liselotte; Holmkvist, Johan; Laurila, Esa; Sjögren, Marketa; Sterner, Maria; Surti, Aarti; Svensson, Margareta; Svensson, Malin; Tewhey, Ryan; Blumenstiel, Brendan; Parkin, Melissa; Defelice, Matthew; Barry, Rachel; Brodeur, Wendy

doi:10.1126/science.1142358

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Shared by NobleBlocks on Jun 1, 2007 • 12:00 AM UTC

Authors:

Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research

Richa Saxena

Benjamin F Voight

Abstract

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, o...

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