Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

Saxena, Richa; F. Voight, Benjamin; Lyssenko, Valeriya; P. Burtt, Noël; I. W. de Bakker, Paul; Chen, Hong; J. Roix, Jeffrey; Kathiresan, Sekar; N. Hirschhorn, Joel; J. Daly, Mark; E. Hughes, Thomas; Groop, Leif; Altshuler, David; Almgren, Peter; C. Florez, José; M. Meyer, Joanne; Ardlie, Kristin; Bengtsson Boström, Kristina; Isomaa, Bo; Lettre, Guillaume; Lindblad, Ulf; N. Lyon, Helen; Melander, Olle; Newton‐Cheh, Christopher; M. Nilsson, Peter; Orho‐Melander, Marju; Råstam, Lennart; K. Speliotes, Elizabeth; Taskinen, Marja‐Riitta; Tuomi, Tiinamaija; Guiducci, Candace; Berglund, Anna; Carlson, Joyce; Gianniny, Lauren; Hackett, Rachel; Hall, Liselotte; Holmkvist, Johan; Laurila, Esa; Sjögren, Marketa; Sterner, Maria; Surti, Aarti; Svensson, Margareta; Svensson, Malin; Tewhey, Ryan; Blumenstiel, Brendan; Parkin, Melissa; DeFelice, Matthew; Barry, Rachel; Brodeur, Wendy; Camarata, Jody; Chia, Nancy; Fava, Mary; G. Gibbons, John; Handsaker, B.; M. Healy, Claire; Nguyen, Christine; Gates, Casey; Sougnez, Carrie; Gage, Diane; M. Nizzari, Marcia; Gabriel, Stacey; Chirn, Gung‐Wei; Ma, Qicheng; Parikh, Hemang; Richardson, Delwood; Ricke, Darrell; Purcell, Shaun

doi:10.1126/science.1142358

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Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

Published in Science • Apr 26, 2007

Authors:

Richa Saxena

Benjamin F. Voight

Valeriya Lyssenko

Abstract

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, o...

Subject

Biology

Single-nucleotide polymorphism

Genetics

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