A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner

R. Donohoe, Dallas; Holley, Darcy; B. Collins, Leonard; A. Montgomery, Stephanie; C. Whitmore, Alan; Hillhouse, Andrew; P. Curry, Kaitlin; W. Renner, Sarah; Greenwalt, Alicia; P. Ryan, Elizabeth; Godfrey, Virginia; T. Heise, Mark; S. Threadgill, Deborah; Han, Anna; A. Swenberg, James; W. Threadgill, David; J. Bultman, Scott

doi:10.1158/2159-8290.cd-14-0501

Public

A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner

Published in Cancer Discovery • Sep 29, 2014

Authors:

Dallas R. Donohoe

Darcy Holley

Leonard B. Collins

Abstract

UNLABELLED: Whether dietary fiber protects against colorectal cancer is controversial because of conflicting results from human epidemiologic studies. However, these studies and mouse models of colorectal cancer have not controlled the composition of gut microbiota, which ferment fiber into short-ch...

Subject

Butyrate

Acetylation

Histone deacetylase inhibitor

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