Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

Mok, Sachel; A. Ashley, Elizabeth; Eduardo Ferreira, Pedro; Zhu, Lei; Lin, Zhaoting; Yeo, Tomas; Chotivanich, Kesinee; Imwong, Mallika; Pukrittayakamee, Sasithon; Dhorda, Mehul; Nguon, Chea; Lim, Pharath; Amaratunga, Chanaki; Suon, Seila; Tinh Hien, Tran; Htut, Ye; Abul Faiz, Mohammad; A. Onyamboko, Marie; Mayxay, Mayfong; N. Newton, Paul; Tripura, Rupam; J. Woodrow, Charles; Miotto, Olivo; Kwiatkowski, Dominic; Nosten, François; Day, Nicholas; R. Preiser, Peter; J. White, Nicholas; M. Dondorp, Arjen; M. Fairhurst, Rick; Bozdech, Zbynek

doi:10.1126/science.1260403

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Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

Published in Science • Dec 12, 2014

Authors:

Sachel Mok

Elizabeth A. Ashley

Pedro Eduardo Ferreira

Abstract

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptomes of...

Subject

Artemisinin

Malaria

Mechanism (biology)

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