Involvement of purinergic signalling in central mechanisms of body temperature regulation in rats

V. Gourine, Alexander; V Melenchuk, Ekaterina; M. Poputnikov, Dmitry; N. Gourine, Valery; Michael Spyer, K.

doi:10.1038/sj.bjp.0704679

Public

Involvement of purinergic signalling in central mechanisms of body temperature regulation in rats

Published in British Journal of Pharmacology • Apr 1, 2002

Authors:

Alexander V. Gourine

Ekaterina V Melenchuk

Dmitry M. Poputnikov

Abstract

1. P2 purinoreceptors are present in hypothalamic and brainstem nuclei that are involved in the regulation of body temperature (T(b)). The role of ATP acting on these P2 receptors in thermoregulation was investigated by studying the effects of the stable ATP analogue alpha,beta-methyleneATP (alpha,b...

Subject

PPADS

Suramin

Thermoregulation

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