Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene

Yamauchi, Atsushi; Ieiri, Ichiro; Kataoka, Yasufumi; Tanabe, Mizuho; Nishizaki, Takashi; Oishi, Ryozo; Higuchi, Shun; Otsubo, Kenji; Sugimachi, Keizō

doi:10.1097/00007890-200208270-00024

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Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene

Published in Transplantation • Aug 1, 2002

Authors:

Atsushi Yamauchi

Ichiro Ieiri

Yasufumi Kataoka

Abstract

BACKGROUND: Tacrolimus is a substrate of P-glycoprotein (PGP) encoded by the multidrug resistant (MDR)1 gene (ABCB1). PGP, a multidrug efflux pump, restricts the distribution of tacrolimus in the brain. In this study, we investigate the correlation of ABCB1 gene polymorphism with tacrolimus-induced ...

Subject

Tacrolimus

Neurotoxicity

Liver transplantation

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