Aldehyde Dehydrogenase 2 Deficiency Ameliorates Alcoholic Fatty Liver but Worsens Liver Inflammation and Fibrosis in Mice

Kwon, Hyo‐Jung; Won, Young-Suk; Park, Ogyi; Chang, Binxia; J. Duryee, Michael; E. Thiele, Geoffrey; Matsumoto, Akiko; Singh, Surendra; A. Abdelmegeed, Mohamed; Song, Byoung‐Joon; Kawamoto, Toshihiro; Vasiliou, Vasilis; M. Thiele, Geoffrey; Gao, Bin

doi:10.1002/hep.27036

Public

Aldehyde Dehydrogenase 2 Deficiency Ameliorates Alcoholic Fatty Liver but Worsens Liver Inflammation and Fibrosis in Mice

Published in Hepatology • Feb 4, 2014

Authors:

Hyo‐Jung Kwon

Young-Suk Won

Ogyi Park

Abstract

UNLABELLED: Aldehyde dehydrogenase 2 (ALDH2) is the major enzyme that metabolizes acetaldehyde produced from alcohol metabolism. Approximately 40-50% of East Asians carry an inactive ALDH2 gene and exhibit acetaldehyde accumulation after alcohol consumption. However, the role of ALDH2 deficiency in ...

Subject

Fatty liver

Aldehyde dehydrogenase

Inflammation

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