Human Extrahepatic Cytochromes P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts

Ding, Xinxin; S. Kaminsky, Laurence

doi:10.1146/annurev.pharmtox.43.100901.140251

Public

Human Extrahepatic Cytochromes P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts

Published in The Annual Review of Pharmacology and Toxicology • Jan 22, 2003

Authors:

Xinxin Ding

Laurence S. Kaminsky

Abstract

Cytochrome P450 (CYP) enzymes in extrahepatic tissues often play a dominant role in target tissue metabolic activation of xenobiotic compounds. They may also determine drug efficacy and influence the tissue burden of foreign chemicals or bioavailability of therapeutic agents. This review focuses on ...

Subject

CYP2A6

Xenobiotic

CYP3A4

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