Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of
                    <i>PGC1</i>
                    and
                    <i>NRF1</i>

Elizabeth Patti, Mary; J. Butte, Atul; Crunkhorn, Sarah; Cusi, Kenneth; Berria, Rachele; Kashyap, Sangeeta; Miyazaki, Yoshinori; Kohane, Isaac; Costello, Maura; Saccone, Robert; J. Landaker, Edwin; B. Goldfine, Allison; Mun, Edward; DeFronzo, Ralph; Finlayson, Jean; Ronald Kahn, C.; J. Mandarino, Lawrence

doi:10.1073/pnas.1032913100

Public

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

Shared by NobleBlocks on Jun 27, 2003 • 12:00 AM UTC

Authors:

Mary Elizabeth Patti

Atul J. Butte

Sarah Crunkhorn

Abstract

Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, glycogen synthesis, and accumulation of i...

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