Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

Caccamo, Antonella; Majumder, Smita; Richardson, Arlan; Strong, Randy; Oddo, Salvatore

doi:10.1074/jbc.m110.100420

Public

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

Published in Journal of Biological Chemistry • Feb 23, 2010

Authors:

Antonella Caccamo

Smita Majumder

Arlan Richardson

Abstract

Accumulation of amyloid-beta (Abeta) and Tau is an invariant feature of Alzheimer disease (AD). The upstream role of Abeta accumulation in the disease pathogenesis is widely accepted, and there is strong evidence showing that Abeta accumulation causes cognitive impairments. However, the molecular me...

Subject

PI3K/AKT/mTOR pathway

Autophagy

Neuroscience

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