NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

M. Gough, Sheryl; Slape, Christopher; D. Aplan, Peter

doi:10.1182/blood-2011-07-328880

Public

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

Published in Blood • Sep 26, 2011

Authors:

Sheryl M. Gough

Christopher Slape

Peter D. Aplan

Abstract

Structural chromosomal rearrangements of the Nucleoporin 98 gene (NUP98), primarily balanced translocations and inversions, are associated with a wide array of hematopoietic malignancies. NUP98 is known to be fused to at least 28 different partner genes in patients with hematopoietic malignancies, i...

Subject

Biology

Fusion gene

Cancer research

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