A CSF‐1 receptor kinase inhibitor targets effector functions and inhibits pro‐inflammatory cytokine production from murine macrophage populations

M. Irvine, Katharine; J. Burns, Christopher; F. Wilks, Andrew; Su, Stephen; Hume, David; J. Sweet, Matthew; M. Irvine, Katharine; J. Burns, Christopher; F. Wilks, Andrew; Su, Stephen; Hume, David; J. Sweet, Matthew

doi:10.1096/fj.06-5848fje

Public

A CSF‐1 receptor kinase inhibitor targets effector functions and inhibits pro‐inflammatory cytokine production from murine macrophage populations

Published in The FASEB Journal • Jul 28, 2006

Authors:

Katharine M. Irvine

Christopher J. Burns

Andrew F. Wilks

Abstract

CSF-1 regulates macrophage differentiation, survival, and function, and is an attractive therapeutic target for chronic inflammation and malignant diseases. Here we describe the effects of a potent and selective inhibitor of CSF-1R-CYC10268-on CSF-1R-dependent signaling. In in vitro kinase assays, C...

Subject

Cytokine

Autocrine signalling

Macrophage colony-stimulating factor

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!