Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

Nährlich, Lutz; G. Mainz, Jochen; Adams, Constantin; Engel, Corinna; Herrmann, Gloria; Icheva, Vanya; Lauer, Josefine; Deppisch, Caroline; Wirth, Andreas; Unger, Katy; Graepler-Mainka, Ute; Hector, Andreas; Heyder, S.; Stern, Martin; Döring, Gerd; Gulbins, Erich; Riethmüller, Joachim

doi:10.1159/000350071

Public

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

Published in Cellular Physiology and Biochemistry • Jan 1, 2013

Authors:

Lutz Nährlich

Jochen G. Mainz

Constantin Adams

Abstract

BACKGROUND/AIMS: Several recent studies revealed an accumulation of ceramide in bronchial, tracheal and intestinal epithelial cells of mice and patients with cystic fibrosis (CF). Normalization of ceramide concentrations in lungs of CF mice employing the functional acid sphingomyelinase inhibitor am...

Subject

Amitriptyline

Placebo

Medicine

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